Monkey Island, it's really fun.
 
Guybrush Threepwood: How can you see without eyeballs?
Murray: How can you walk around without a brain? Some things no one can answer.
 
PS: Murray is a talking skull
 
Grim Fandango, also very fun.
 
Hector LeMans: Oh Manny... so cynical... What happened to you, Manny, that caused you to lose your sense of hope, your love of life?
Manuel Calavera: I died.
				
			Guybrush Threepwood: How can you see without eyeballs?
Murray: How can you walk around without a brain? Some things no one can answer.
PS: Murray is a talking skull
Grim Fandango, also very fun.
Hector LeMans: Oh Manny... so cynical... What happened to you, Manny, that caused you to lose your sense of hope, your love of life?
Manuel Calavera: I died.
	
 Monkey Island--the whole series, most EA games and one other that I don't think was mentioned...
