These are the places I usually hit when I venture into downtown Seattle:
Barney's New York: All the usual Barney's stuff, with nice salespeople, and $6 all-day Saturday parking. I-5 south to Union street exit, right on 6th Ave, then immediately look for the sign on the left advertising $6 parking. Do not be led astray by the Washington Athletic Club parking on the same block, which is highway robbery at $8.50 for 3 hours.
Nordstrom Flagship store at Pine and 6th Ave: handbag heaven, with Chanel, YSL, and Ferragamo boutiques, also Chloe, Celine, Jimmy Choo, etc. Upstairs designer boutiques include Chanel, YSL, Alexander McQueen, Piazza Sempione. Very friendly service, classic Nordstrom, even in the Chanel boutiques. You can get bandages for your shopping-damaged feet at the customer service desk near shoes.
Mario's, 1513 6th Ave: Menswear downstairs, women's upstairs. Upscale European designer brands: Etro, Prada, Chloe, Tod's, Dolce & Gabbana, Valentino, Oscar de la Renta, Jil Sander, Lanvin, Marc Jacobs, Narciso Rodriguez, Christian Louboutin. Creed fragrances.
Alhambra, 101 Pine Street: an eclectic mix--Trina Turk, Wyeth, Tracy Reese, Edward An, Nanette Lepore, Lisa Nading, Gentle Souls.
Betty Blue, 608 Second Ave: Last season's upscale designer pieces at a discount: Comme des Garcons, Yohji Yamamoto, Y3, Rick Owens, Stella McCartney, Valentino, Dolce & Gabbana, Dries van Noten, Christian Dior, Balenciaga.
Baby & Co, 1936 1st Ave: Avante-garde clothing. Marithe and Francois Girbaud, Lilith, Shirin Guild, Comme des Garcons. Avoids trends...to the point of being bizarre, sometimes.
J. Gilbert footwear, 2025 1st Ave: unusual, pricey, comfortable, stylish footwear that fits my wide feet. Also some clothes and interesting handbags.
Jeri Rice, 421 University St: An elegant friend of mine really likes this store. However, I've never found anything very interesting there. It carries conservative lines of Akris, Blumarine, Burberry, Celine, Loro Piana, Milly, Ralph Lauren, etc.
Nordstrom Rack: discount Nordstrom's ware. Spotty; but you can sometimes make out like a bandit. I got some fab Ferragamo spectators in a C-width once. This is my husband's favorite store, as the menswear selection is very good.
All of the above have excellent and very friendly service. Too friendly, sometimes!
My usual pattern is park at Barney's, go to Barney's, then Mario's, Nordstrom, Alhambra, Baby & Co., J. Gilbert. If I'm not exhausted by then, I'll head towards Jeri Rice, which is also flanked by Louis Vuitton and Escada. Betty Blue is in the Pioneer Square neighborhood of Seattle, which is also known for its art galleries, so I usually go there as a break from art browsing.