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sky.comThe 40-year-old was discovered at his property in Green Street, in London's West End.
He is believed to have become depressed following the death of his mum Joyce, a week ago.
McQueen, who won British fashion designer four times between 1996 and 2003, had posted a string of messages on Twitter offering an insight into his state of mind.
The last message on his account was: "im here with my girl annie tinkerbell wishing kerry the slag, happy birthday in NY, your 40 now girl time to slow it down we think."
The unusual tweets began when his mother passed away.
On February 3 he wrote: "i'm letting my followers know the my mother passed away yesterday if it she had not me nor would you RIP mumxxxxxxxxxxxxxxxxxxxxxxxxxxx"
This was completed seconds later with "but life must go on!!!!!!!!!!!!!!!"
Then four days later over two tweets he wrote: "sunday evening been a f*****g awful week but my friends have been great but now i have to some how pull myself together and finish with the HELLS ANGLES & PROLIFIC DEAMONS!!!!!!!!!!!!!!!!!!!!!!!"
Police said his death is not being treated as suspicious.
A spokeswoman for Mr McQueen said: "Mr McQueen was found dead this morning at his home. We're devastated and I hope you understand that out of respect to his family and his colleagues we're not going to be making any further statement."