Merged with the existing thread about this topic. Read it ... it's not an uncommon question and you can see what others think about this.
IMO, you can start your own line ... if you want to design but can't meet the educational requirements to work for another designer. But to run your own business sucessfully, you must have business/entreprenurial skills, financial backing and advisors and a way of finding someone to sell your line to, or it probably won't work. So ... some education and lots and lots of experience in the biz is pretty much a necessary thing ... if you want to work as a desinger or for a designer.
Creativity won't get you far. Connections are probably the #1 asset you need to get hired, backed up with knowledge of your craft and experience doing it. That usually begins by studying in the feild that you want to work in. A design firm probably won't hire you to design or even to assist a designer, unless you have the credentials and the experience that comes doing college internships and such. You can't even work as a pattern designer if you don't know what you are doing.
Remember ... you will compete with all of those thousands of talented and experienced graduates from various fashion schools. So ... you will have to have something very very special to be considered ... you must be able to hit the ground running to earn your salary.
Yeah ... you might land a job as a personal assistant or a receptionist for a fashion company without specific training in fashion design ... but that generally won't get help you actually become a designer. You might get in the door, but unless you can demonstrate your design and sewing skills somehow ... it probably won't get you far, either.
School ... and connections. That is what I recommend.
Now, for other things like PR and publishing in the fashion arena ... your education doesn't need to be fashion specific ... and often they hire people they know and like, rather than a brand new fashion school graduate. And they will promote the occassional shining star who may have shown talent (writing and being creative) and self reliance. So connections and creativity might work in these feilds, if you can impress them somehow.